منابع مشابه
Vaccines against dangerous pathogens.
Dangerous pathogens are defined by the UK Health and Safety Executive's advisory committee as category 3 (those which cause severe human disease for which prophylaxis or therapy is usually available) or category 4 (as for category 3, but for which prophylaxis or therapy is not available). Research and development of vaccines for such pathogens is challenging, due to the safety constraints in th...
متن کاملGuarding against the most dangerous emerging pathogens.
Control of emerging infectious diseases will be difficult because of the large number of disease-causing organisms that are emerging or could emerge and the great diversity of geographic areas in which emergence can occur. The modern view of the evolution of pathogen virulence--specifically its focus on the tradeoff between costs and benefits to the pathogen from increased host exploitation--al...
متن کاملThe dangerous impurities of vaccines
In 1998 and 1999 scientists representing the World Health Organization (WHO) met with the senior vaccine regulatory scientists of the USA and UK at the National Institutes of Health (NIH) in Washington D.C. to discuss the safety of the manufacturing methods employed to produce vaccines. No journalists were present but official transcripts were kept. What they record is that all the many experts...
متن کاملEpitope Driven Broad Spectrum Peptide Vaccines against MDR Pathogens
Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia have evolved as a group of co-existing multidrug resistant nosocomial pathogens spreading worldwide. Overuse of antibiotics has led to the emergence of pan drug resistant bacterial strains and has made all antimicrobial agents superfluous including carbapenems and even the last resort antibiotic-colistin, resulting in high...
متن کاملGenome-based approaches to develop vaccines against bacterial pathogens.
Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the way to think about vaccine development, enabling the targeting of possible vac...
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ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 2002
ISSN: 1471-8391,0007-1420
DOI: 10.1093/bmb/62.1.163